Selected from 58 publications:
1. Liu, T., Ghosal, G., Yuan, J., Chen, J.*, and Huang, J.* (2010) FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science 329, 693-696.
2. Su, X., and Huang, J.* (2011) The Fanconi anemia pathway and DNA interstrand cross-link repair. Protein Cell 2, 704-711. (Invited reivew)
3. Liu, T., Wan, L., Wu, Y., Chen, J.*, and Huang, J.* (2011) hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. J. Biol. Chem. 286, 41758-41766.
4. Wang, W., Huang, J.*, and Chen, J.* (2011) Angiomotin-like proteins associate with and negatively regulate YAP1. J. Biol. Chem. 286, 4364-4370.
5. Liu, T., Chen, H., Kim, H., Huen, M.S., Chen, J.*, and Huang, J.* (2012) RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair 11, 131-138.
6. Wan, L., Han, J., Liu, T., Dong, S., Xie, F., Chen, H., and Huang, J.* (2013) Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair. Proc. Natl. Acad. Sci. U. S. A. 110, 10646-10651.
7. Wan, L., Lou, J., Xia, Y., Su, B., Liu, T., Cui, J., Sun, Y., Lou, H.*., and Huang, J.* (2013) hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. EMBO Rep. 14, 1104-1112.
8. Wan, L., Huang, J.* (2014) The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasia-mutated and Rad3-related (ATR). J. Biol. Chem. 289, 6619-6626.
9. Ren, W., Chen, H., Sun, Q., Tang, X.,
10. Liu, T.*., and Huang, J.* (2014) Quality control of homologous recombination. Cell. Mol. Life Sci. 71, 3779-3797. (Invited reivew)
11. Han, J., Liu, T., Huen, M.S., Hu, L., Chen, Z., and Huang, J.* (2014) SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination. J. Cell Biol. 205, 811-827.
12. Dong, S., Han, J., Chen, H., Liu, T., Huen, M.S., Yang, Y., Guo, C., and Huang, J.* (2014) The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection. Curr. Biol. 24, 2097-2110.
13. Wu, Y., Chen, H., Lu, J., Zhang, M., Zhang, R., Duan, T., Wang, X., Huang, J.*, and Kang, T.* (2015) Acetylation-dependent function of human single-stranded DNA binding protein 1. Nucleic Acids Res. 43, 7878-87.
14. Mu, Y., Lou, J., Srivastava, M., Zhao, B., Feng, X.H., Liu, T*.., Chen, J.*., and Huang, J.* (2016) SLFN11 inhibits checkpoint maintenance and homologous recombination repair. EMBO Rep. 17, 94-109.
15. Han, J., Ruan, C., Huen, M., He, H., Wang., J., Xie, A., Fu, C., Liu, T., Huang, J.* (2017) BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability. Nat. Commun. 8, 1470-1458.
16. Lou, J., Chen, H., Han, J., Feng, X.H., Liu, T., and Huang, J.* (2017) AUNIP directs DNA double-strand breaks towards the homologous recombination repair pathway. Nat. Commun. 8, 985-1001.
17. Tian, T., Bu, M., Chen, X., Ding, L., Yang, Y,, Han, J., Feng, X., Xu, P., Liu, T., Ying, S., Lei, Y., Li, Q., and Huang, J.* (2021) The ZATT-TOP2A-PICH Axis Drives Extensive Replication Fork Reversal to Promote Genome Stability. Mol. Cell 81, 198-211.
18. Han, J., Wan, L., Jiang, G., Cao, L., Xia, F., Tian, T., Zhu, X., Wu, M., Huen, M.S., Wang, Y., Liu, T.*, and Huang, J.* (2021) ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP. Proc. Natl. Acad. Sci. U. S. A. 118, e2022600118.
19. Dai, L., Dai, Y., Han, J., Huang, Y., Wang, L., Huang, J.*, and Zhou, Z.* (2021) Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin. Mol. Cell 81, 2765-2777.
20. Jia, Y., Cheng, Z., Bharath, SR., Sun, Q., Su, N., Huang, J.*, and Song, H.* (2021) Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair. Cell Discov. 7, 66.
21. Zhu, Y., Wang, Y., Tao, B., Han, J., Chen, H., Zhu, Q., Huang, L., He, Y., Hong, J., Li, Y., Chen, J., Huang, J.*, Lo, LJ.*, and Peng, J. * (2021) Nucleolar GTPase Bms1 displaces Ttf1 from RFB-sites to balance progression of rDNA transcription and replication. J. Mol. Cell Biol.mjab074.Online ahead of print.
22.Ding L, Luo Y, Tian T, Chen X, Yang Y, Bu M, Han J, Yang B, Yan H, Liu T, Wu M, Zhang G, Xu Y, Zhu S, Huen MSY, Mao G, Huang J.*(2022) RNF4 controls the extent of replication fork reversal to preserve genome stability. Nucleic Acids Res. 10;50(10):5672-5687.
23. Zhang, Q., Fan, J., Xu, W., Cao, H., Qiu, C., Xiong, Y., Zhao, H., Wang, Y., Huang, J.*, Yu, C. (2023)The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart. Nucleic Acids Res. 8;51(16):8606-8622.
24.Zhu, X., Su, Q., Xie, H., Song, L., Yang, F., Zhang, D., Wang, B., Lin, S., Huang, J.*, Wu, M., Liu, T. (2023) SIRT1 deacetylates WEE1 and sensitizes cancer cells to WEE1 inhibition. Nat Chem Biol.;19(5):585-595.
25. Tian, T., Chen, J., Zhao, H., Li, Y., Xia, F., Huang, J.*, Han, J., Liu, T. (2024)UFL1 triggers replication fork degradation by MRE11 in BRCA1/2-deficient cells. Nat Chem Biol..
26.Chen, J., Wu, M., Yang, Y., Ruan, C., Luo, Y., Song, L., Wu, T., Huang, J.*, Yang, B., Liu, T. (2024)TFIP11 promotes replication fork reversal to preserve genome stability.(2024) Nat Commun. 2024 Feb 10;15(1):1262.
27. Song, L., Xie, H., Fan, H., Zhang, Y., Cheng, Z., Chen, J., Guo, Y., Zhang, S., Zhou, X., Li, Z., Liao, H., Han, J., Huang, J., Zhou, J., Fang, D., Liu, T.(2025) Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A. Mol Cell. 2025 Feb 6;85(3):506-522.e7. Epub 2024 Dec 19.
28. Xie, H., Song, L., Mao, G., Han, J., Pu, J., Wu, Z., Chen, J., Zhou, J., Huang, J., Fang, D., Liu, T. (2025)Synergistic protection of nascent DNA at stalled forks by MSANTD4 and BRCA1/2-RAD51. Nat Chem Biol.2025 Aug;21(8):1182-1193. doi: 10.1038/s41589-024-01833-9. Epub 2025 Jan 14.
29. Li, Z., Liu, Y., Liu, Y., Zhang, Y., Huen, MSY., Lu, H., Zhang, Z., Zhou, J., Fang, D., Liu, T., Huang, J.(2025)The PARP1-EXD2 axis orchestrates R-loop resolution to safeguard genome stability. Nat Chem Biol. 2025 Jun 27.